4-Amino-1-butanol → HCID 19369795, compound

HRID 849171Notes

Reaction equation

HRID 849171 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([O:21][C:22]([F:25])([F:24])[F:23])[C:14]=3[N:13]=[C:12](Cl)[C:11]=2[CH2:10][CH2:9]1.[NH2:27][CH2:28][CH2:29][CH2:30][CH2:31][OH:32]>C(O)COCCO>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([O:21][C:22]([F:25])([F:24])[F:23])[C:14]=3[N:13]=[C:12]([NH:27][CH2:28][CH2:29][CH2:30][CH2:31][OH:32])[C:11]=2[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 258684-Amino-1-butanolHCID 11728593HCID 11728593, compound

Product 1

HCID 19369795HCID 19369795, compound

Reagents, catalysts & solvents 1

HCID 8117Diethylene GlycolSolvent

Procedure

1-(2-Methylphenyl)-4-chloro-6-trifluoromethoxy-2,3-dihydropyrrolo[3,2-c]quinoline(600 mg, 1.6 mmol) was dissolved in diethylene glycol(10 ml) and hereto was added 4-amino-1-butanol(1.0 ml), then reacted at the same condition of Step 5 in the Example 1 to obtain 510 mg of desired compound as solid in 73% of yield.

Workup

  1. customreacted at the same condition of Step 5 in the Example 1

Sources & evidence

ORD record
ord-0f41c1767b2742c1b8dc206d5f1b0644
Source dataset
uspto-grants-2000_01
Patent number
US06011044

Reaction notes

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