3-Amino-1-propanol → HCID 19369765, compound

HRID 849173Notes

Reaction equation

HRID 849173 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([O:21][C:22]([F:25])([F:24])[F:23])[C:14]=3[N:13]=[C:12](Cl)[C:11]=2[CH:10]=[CH:9]1.[NH2:27][CH2:28][CH2:29][CH2:30][OH:31]>>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([O:21][C:22]([F:25])([F:24])[F:23])[C:14]=3[N:13]=[C:12]([NH:27][CH2:28][CH2:29][CH2:30][OH:31])[C:11]=2[CH:10]=[CH:9]1

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 17872147HCID 17872147, compound

Product 1

HCID 19369765HCID 19369765, compound

Procedure

1-(2-Methylphenyl)-4-chloro-6-trifluoromethoxypyrrolo[3,2-c]quinoline(377 mg, 1.0 mmol) was dissolved in 3-amino-1-propanol(10 ml) in the pressure tube, then reacted at the same condition of Step 3 in the Example 6 to obtain 303 mg of desired compound as solid in 73% of yield.

Workup

  1. customreacted at the same condition of Step 3 in the Example 6

Sources & evidence

ORD record
ord-926b6ea49bbd4bbd9ea7f7d7106b4933
Source dataset
uspto-grants-2000_01
Patent number
US06011044

Reaction notes

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