3-Amino-1-propanol → HCID 19369848, compound

HRID 849188Notes

Reaction equation

HRID 849188 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:21]2[C:20]3[CH:19]=[CH:18][CH:17]=[C:16]([O:22][C:23]([F:26])([F:25])[F:24])[C:15]=3[N:14]=[C:13](Cl)[C:12]=2[CH2:11][CH2:10]1.[NH2:28][CH2:29][CH2:30][CH2:31][OH:32]>>[CH3:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:21]2[C:20]3[CH:19]=[CH:18][CH:17]=[C:16]([O:22][C:23]([F:26])([F:25])[F:24])[C:15]=3[N:14]=[C:13]([NH:28][CH2:29][CH2:30][CH2:31][OH:32])[C:12]=2[CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 19369839HCID 19369839, compound

Product 1

HCID 19369848HCID 19369848, compound

Procedure

1-(2-Methyl-4-fluorophenyl)-4-chloro-6-trifluoromethoxy-2,3-dihydropyrrolo[3,2-c]quinoline(500 mg, 1.3 mmol) was dissolved in 3-amino-1-propanol(10 ml) in the pressure tube, then reacted at the same condition of Step 3 in the Example 16 to obtain 485 mg of desired compound as solid in 95% of yield.

Workup

  1. customreacted at the same condition of Step 3 in the Example 16

Sources & evidence

ORD record
ord-ff7404068ce1450cab78ce244f2c0c53
Source dataset
uspto-grants-2000_01
Patent number
US06011044

Reaction notes

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