HCID 19369839, compound → HCID 19369831, compound

HRID 849189Notes

Reaction equation

HRID 849189 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:21]2[C:20]3[CH:19]=[CH:18][CH:17]=[C:16]([O:22][C:23]([F:26])([F:25])[F:24])[C:15]=3[N:14]=[C:13](Cl)[C:12]=2[CH2:11][CH2:10]1>NCCCCO>[CH3:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:21]2[C:20]3[CH:19]=[CH:18][CH:17]=[C:16]([O:22][C:23]([F:26])([F:25])[F:24])[C:15]=3[N:14]=[C:13]([NH:9][CH2:21][CH2:20][CH2:15][CH2:16][OH:22])[C:12]=2[CH2:11][CH2:10]1

Participants

3

Reactant 1

HCID 19369839HCID 19369839, compound

Product 1

HCID 19369831HCID 19369831, compoundYield 133.5%

Reagents, catalysts & solvents 1

HCID 258684-Amino-1-butanolSolvent

Procedure

1-(2-methyl-4-fluorophenyl)-4-chloro-6-trifluoromethoxy-2,3-dihydro-pyrrolo[3,2-c]quinoline(500 mg, 1.3 mmol) was dissolved in 4-amino-1-butanol(5 ml) in the pressure tube, then reacted at the same condition of Step 3 in the Example 16 to obtain 390 mg of desired compound as solid in 74% of yield.

Workup

  1. customreacted at the same condition of Step 3 in the Example 16

Sources & evidence

ORD record
ord-c49af5e12f4c43d49bbc731bb6ae0acf
Source dataset
uspto-grants-2000_01
Patent number
US06011044

Reaction notes

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