3-Amino-1-propanol → HCID 19369793, compound

HRID 849192Notes

Reaction equation

HRID 849192 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:21]2[C:20]3[CH:19]=[CH:18][CH:17]=[C:16]([O:22][C:23]([F:26])([F:25])[F:24])[C:15]=3[N:14]=[C:13](Cl)[C:12]=2[CH:11]=[CH:10]1.[NH2:28][CH2:29][CH2:30][CH2:31][OH:32]>>[CH3:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:21]2[C:20]3[CH:19]=[CH:18][CH:17]=[C:16]([O:22][C:23]([F:26])([F:25])[F:24])[C:15]=3[N:14]=[C:13]([NH:28][CH2:29][CH2:30][CH2:31][OH:32])[C:12]=2[CH:11]=[CH:10]1

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 19369780HCID 19369780, compound

Product 1

HCID 19369793HCID 19369793, compound

Procedure

1-(2-Methyl-4-fluorophenyl)-4-chloro-6-trifluoromethoxypyrrolo[3,2-c]quinoline(394 mg, 1.0 mmol) was dissolved in 3-amino-1-propanol(5 ml) in the pressure tube, and reacted at the same condition of Step 3 in the Example to obtain 460 mg of desired compound as solid in 83% of yield.

Sources & evidence

ORD record
ord-d669a3d625c348b5b492cf80d25c621d
Source dataset
uspto-grants-2000_01
Patent number
US06011044

Reaction notes

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