3-Amino-1-propanol → HCID 19369799, compound

HRID 849200Notes

Reaction equation

HRID 849200 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([O:21][CH2:22][C:23]([F:26])([F:25])[F:24])[C:14]=3[N:13]=[C:12](Cl)[C:11]=2[CH2:10][CH2:9]1.[NH2:28][CH2:29][CH2:30][CH2:31][OH:32]>>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([O:21][CH2:22][C:23]([F:26])([F:25])[F:24])[C:14]=3[N:13]=[C:12]([NH:28][CH2:29][CH2:30][CH2:31][OH:32])[C:11]=2[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 19369789HCID 19369789, compound

Product 1

HCID 19369799HCID 19369799, compound

Procedure

1-(2-Methylphenyl)-4-chloro-6-β,β,β-trifluoroethoxy-2,3-dihydropyrrolo[3,2-c]quinoline(500 mg, 1.3 mmol) was dissolved in 3-amino-1-propanol(5.0 ml), and reacted at the same condition of Step 6 in the Example 30 to obtain 496 mg of desired compound as solid in 90% of yield.

Workup

  1. customreacted at the same condition of Step 6 in the Example 30

Sources & evidence

ORD record
ord-d148c468b4fb42eca10a8545ce354933
Source dataset
uspto-grants-2000_01
Patent number
US06011044

Reaction notes

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