3-Amino-1-propanol → HCID 19369779, compound

HRID 849208Notes

Reaction equation

HRID 849208 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:21]2[C:20]3[CH:19]=[CH:18][CH:17]=[C:16]([O:22][CH2:23][C:24]([F:27])([F:26])[F:25])[C:15]=3[N:14]=[C:13](Cl)[C:12]=2[CH2:11][CH2:10]1.[NH2:29][CH2:30][CH2:31][CH2:32][OH:33]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:21]2[C:20]3[CH:19]=[CH:18][CH:17]=[C:16]([O:22][CH2:23][C:24]([F:27])([F:26])[F:25])[C:15]=3[N:14]=[C:13]([NH:29][CH2:30][CH2:31][CH2:32][OH:33])[C:12]=2[CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 19369785HCID 19369785, compound

Product 1

HCID 19369779HCID 19369779, compound

Procedure

1-(2-Methoxyphenyl)-4-chloro-6-β,β,β-trifluoroethoxy-2,3-dihydro-pyrrolo[3,2-c]quinoline(500 mg, 1.2 mmol) was dissolved in 3-amino-1-propanol(5.0 ml), and reacted at the same condition of Step 3 in the Example 38 to obtain 425 mg of desired compound as solid in 77% of yield.

Workup

  1. customreacted at the same condition of Step 3 in the Example 38

Sources & evidence

ORD record
ord-ea08f2da4b4545dba59507574e3303e8
Source dataset
uspto-grants-2000_01
Patent number
US06011044

Reaction notes

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