4-Amino-1-butanol → HCID 19369833, compound

HRID 849209Notes

Reaction equation

HRID 849209 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:21]2[C:20]3[CH:19]=[CH:18][CH:17]=[C:16]([O:22][CH2:23][C:24]([F:27])([F:26])[F:25])[C:15]=3[N:14]=[C:13](Cl)[C:12]=2[CH2:11][CH2:10]1.[NH2:29][CH2:30][CH2:31][CH2:32][CH2:33][OH:34]>C(O)COCCO>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:21]2[C:20]3[CH:19]=[CH:18][CH:17]=[C:16]([O:22][CH2:23][C:24]([F:27])([F:26])[F:25])[C:15]=3[N:14]=[C:13]([NH:29][CH2:30][CH2:31][CH2:32][CH2:33][OH:34])[C:12]=2[CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 258684-Amino-1-butanolHCID 19369785HCID 19369785, compound

Product 1

HCID 19369833HCID 19369833, compoundYield 21.7%

Reagents, catalysts & solvents 1

HCID 8117Diethylene GlycolSolvent

Procedure

1-(2-Methoxyphenyl)-4-chloro-6-β,β,β-trifluoroethoxy-2,3-dihydropyrrolo[3,2-c]quinoline(500 mg, 1.2 mmol) was dissolved in diethylene glycol(10 ml) and 4-amino-1-butanol(175 μl, 1.9 mmol) was added. It was reacted at the same condition of Step 3 in the Example 38 to obtain 120 mg of desired compound as solid in 39% of yield.

Workup

  1. customIt was reacted at the same condition of Step 3 in the Example 38

Sources & evidence

ORD record
ord-94a60ca93df04f18bff9d4e3172d2149
Source dataset
uspto-grants-2000_01
Patent number
US06011044

Reaction notes

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