3-Amino-1-propanol → HCID 19369850, compound

HRID 849212Notes

Reaction equation

HRID 849212 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:21]2[C:20]3[CH:19]=[CH:18][CH:17]=[C:16]([O:22][CH2:23][C:24]([F:27])([F:26])[F:25])[C:15]=3[N:14]=[C:13](Cl)[C:12]=2[CH2:11][CH2:10]1.[NH2:29][CH2:30][CH2:31][CH2:32][OH:33]>>[CH3:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:21]2[C:20]3[CH:19]=[CH:18][CH:17]=[C:16]([O:22][CH2:23][C:24]([F:27])([F:26])[F:25])[C:15]=3[N:14]=[C:13]([NH:29][CH2:30][CH2:31][CH2:32][OH:33])[C:12]=2[CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 19369782HCID 19369782, compound

Product 1

HCID 19369850HCID 19369850, compound

Procedure

1-(2-Methyl-4-fluorophenyl)-4-chloro-6-β,β,β-trifluoroethoxy-2,3-dihydropyrrolo[3,2-c]quinoline(600 mg, 1.4 mmol) was dissolved in 3-amino-1-propanol(5.0 ml). The reaction mixture was reacted at the same condition of Step 3 in the Example 42 to obtain 520 mg of desired compound as solid in 84% of yield.

Workup

  1. customThe reaction mixture was reacted at the same condition of Step 3 in the Example 42

Sources & evidence

ORD record
ord-5f1e1352f54a4ca887162de992bca5e7
Source dataset
uspto-grants-2000_01
Patent number
US06011044

Reaction notes

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