3-Amino-1-propanol → HCID 19369847, compound

HRID 849220Notes

Reaction equation

HRID 849220 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[N:10]1[C:22]2[C:21]3[CH:20]=[CH:19][CH:18]=[C:17]([O:23][CH2:24][C:25]([F:28])([F:27])[F:26])[C:16]=3[N:15]=[C:14](Cl)[C:13]=2[CH2:12][CH2:11]1.[NH2:30][CH2:31][CH2:32][CH2:33][OH:34]>>[CH3:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[N:10]1[C:22]2[C:21]3[CH:20]=[CH:19][CH:18]=[C:17]([O:23][CH2:24][C:25]([F:28])([F:27])[F:26])[C:16]=3[N:15]=[C:14]([NH:30][CH2:31][CH2:32][CH2:33][OH:34])[C:13]=2[CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 19369819HCID 19369819, compound

Product 1

HCID 19369847HCID 19369847, compound

Procedure

1-(2-Methyl-4-methoxyphenyl)-4-chloro-6-β,β,β-trifluoroethoxy-2,3-dihydropyrrolo[3,2-c]quinoline(700 mg, 1.7 mmol) was dissolved in 3-amino-1-propanol(5.0 ml), and reacted at the same condition of Step 3 in the Example 49 to obtain 470 mg of desired compound as solid in 60% of yield.

Workup

  1. customreacted at the same condition of Step 3 in the Example 49

Sources & evidence

ORD record
ord-9880467f6e314bbab1c8ca543de5f695
Source dataset
uspto-grants-2000_01
Patent number
US06011044

Reaction notes

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