3-Amino-1-propanol → HCID 19369792, compound

HRID 849222Notes

Reaction equation

HRID 849222 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([O:21][CH2:22][C:23]([F:29])([F:28])[C:24]([F:27])([F:26])[F:25])[C:14]=3[N:13]=[C:12](Cl)[C:11]=2[CH2:10][CH2:9]1.[NH2:31][CH2:32][CH2:33][CH2:34][OH:35]>>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([O:21][CH2:22][C:23]([F:29])([F:28])[C:24]([F:27])([F:26])[F:25])[C:14]=3[N:13]=[C:12]([NH:31][CH2:32][CH2:33][CH2:34][OH:35])[C:11]=2[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 19369781HCID 19369781, compound

Product 1

HCID 19369792HCID 19369792, compound

Procedure

1-(2-Methylphenyl)-4-chloro-6-β,β,γ,γ,γ-pentafluoropropyloxy-2,3-dihydropyrrolo[3,2-c]quinoline(570 mg, 1.2 mmol) was dissolved in 3-amino-1-propanol(5.0 ml), and reacted at the same condition of Step 6 in the Example 57 to obtain 260 mg of desired compound as solid in 42% of yield.

Workup

  1. customreacted at the same condition of Step 6 in the Example 57

Sources & evidence

ORD record
ord-8beac5aaa59d42ed8294a33ea8d8b8fd
Source dataset
uspto-grants-2000_01
Patent number
US06011044

Reaction notes

Loading…