3-Amino-1-propanol → HCID 19369842, compound

HRID 849226Notes

Reaction equation

HRID 849226 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([O:21][CH2:22][C:23]([F:29])([F:28])[C:24]([F:27])([F:26])[F:25])[C:14]=3[N:13]=[C:12](Cl)[C:11]=2[CH:10]=[CH:9]1.[NH2:31][CH2:32][CH2:33][CH2:34][OH:35]>>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([O:21][CH2:22][C:23]([F:29])([F:28])[C:24]([F:27])([F:26])[F:25])[C:14]=3[N:13]=[C:12]([NH:31][CH2:32][CH2:33][CH2:34][OH:35])[C:11]=2[CH:10]=[CH:9]1

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 19369808HCID 19369808, compound

Product 1

HCID 19369842HCID 19369842, compound

Procedure

1-(2-Methylphenyl)-4-chloro-6-β,β,γ,γ,γ-pentafluoropropyloxypyrrolo[3,2-c]quinoline(600 mg, 1.4 mmol) was dissolved in 3-amino-1-propanol(5.0 ml), and reacted at the same condition of Step 3 in the Example 59 to obtain 610 mg of desired compound as solid in 94% of yield.

Workup

  1. customreacted at the same condition of Step 3 in the Example 59

Sources & evidence

ORD record
ord-e256d7505d6b4ce1a3dc7bf3790f0ed1
Source dataset
uspto-grants-2000_01
Patent number
US06011044

Reaction notes

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