Hydrochloric Acid → 2-Amino-4,4,4-trifluorobutanamide hydrochloride

HRID 84924Notes

Reaction equation

HRID 84924 reaction equation
[NH2:1][C:2](=[O:17])[CH:3]([NH:9]C(=O)OC(C)(C)C)[CH2:4][C:5]([F:8])([F:7])[F:6].[ClH:18]>O1CCOCC1>[ClH:18].[NH2:9][CH:3]([CH2:4][C:5]([F:8])([F:7])[F:6])[C:2]([NH2:1])=[O:17]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86666168Tert-butyl 1-amino-4,4,4-trifluoro-1-oxobutan-2-ylcarbamate

Product 1

HCID 866661692-Amino-4,4,4-trifluorobutanamide hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of the solid tert-butyl 1-amino-4,4,4-trifluoro-1-oxobutan-2-ylcarbamate in dioxane (4 mL) and aq. 6N HCl (6 mL) was stirred at room temperature for 1 h. It was then concentrated in vacuo to give 2-amino-4,4,4-trifluorobutanamide hydrochloride as a solid (135 mg).

Workup

  1. concentrationIt was then concentrated in vacuo

Sources & evidence

ORD record
ord-8cee082e5e834c4b916c5319656b98d9
Source dataset
uspto-grants-2014_09
Patent number
US08846928B2

Reaction notes

Loading…