反应详情

The compound of Example 41 (10.0 g, 50 mmole) is dissolved in tetrabutylammonium flouride (120 mL of a 1.0M solution in tetrahydrofuran, 0.124 mole). Ethyl bromoacetate (8.3 mL, 75 mmole) is added. The reaction mixture is stirred at room temperature. The reaction mixture is concentrated, then partitioned between dichloromethane and water. The aqueous layer is extracted with dichloromethane. The combined organic extracts are washed with water, brine, and dried over anhydrous magnesium sulfate. The solvent is removed under vacuum to afford the title compound.

1. concentrationThe reaction mixture is concentrated
2. custompartitioned between dichloromethane and water
3. extractionThe aqueous layer is extracted with dichloromethane
4. washThe combined organic extracts are washed with water, brine
5. dry with materialdried over anhydrous magnesium sulfate
6. customThe solvent is removed under vacuum