Ethyl 5-nitro-1-methoxymethyl-3-uracilylacetate → Ethyl 5-amino-1-methoxymethyluracilylacetate

Participants

Reaction Steps

A stirred solution of the compound of Example 42 (10.0 g, 35 mmole) in ethanol (100 mL) is hydrogenated over 10% Pd/C (1.00 g) for 8 hours under balloon pressure. Celite is added, and the reaction mixture is filtered through a pad of celite, using ethyl acetate to wash. The solvent is removed in vacuo to give crude ethyl 5-amino-1-methoxymethyl-uracilylacetate.

Provenance & Evidence