Trifluoroacetic acid → HCID 22943378, compound

HRID 849298Notes

Reaction equation

HRID 849298 reaction equation
[CH2:1]([O:4][C:5]([NH:7][C:8]1[C:9](=[O:20])[N:10]([CH2:14][C:15]([O:17]CC)=[O:16])[CH:11]=[CH:12][CH:13]=1)=[O:6])[CH:2]=[CH2:3].FC(F)(F)C(O)=O>ClCCl.C1(C)C=CC=CC=1>[CH2:1]([O:4][C:5]([NH:7][C:8]1[C:9](=[O:20])[N:10]([CH2:14][C:15]([OH:17])=[O:16])[CH:11]=[CH:12][CH:13]=1)=[O:6])[CH:2]=[CH2:3]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57242741HCID 57242741, compound

Product 1

HCID 22943378HCID 22943378, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 6344DichloromethaneSolvent

Procedure

The compound of example 60 (1.00 g) is treated with 50% trifluoroacetic acid in dichloromethane (10 mL) for 1 hour at 0° C., and 3 hours at room temperature. The solution is diluted with toluene (50 mL) and the solvent is removed in vacuo to afford the title compound.

Workup

  1. custom3 hours
  2. customat room temperature
  3. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-6374e95d9acc4a47b84e488217b56566
Source dataset
uspto-grants-2000_01
Patent number
US06011158

Reaction notes

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