HCID 19591399, compound → 4-Phenyl-1-azabicyclo(2.2.2)octane

HRID 849343Notes

Reaction equation

HRID 849343 reaction equation
[Cl-].ClC1C=C(C2(CC[N+:34]34[CH2:41][CH2:40][C:37]([C:42]5[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=5)([CH2:38][CH2:39]3)[CH2:36][CH2:35]4)CN(CC3C=C(C(F)(F)F)C=C(C(F)(F)F)C=3)C(=O)N2C)C=CC=1Cl>CN(C=O)C>[C:42]1([C:37]23[CH2:40][CH2:41][N:34]([CH2:35][CH2:36]2)[CH2:39][CH2:38]3)[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=1

Participants

3

Reactant 1

HCID 19591399HCID 19591399, compound

Product 1

HCID 1428104-Phenyl-1-azabicyclo(2.2.2)octane

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4-(3,4-Dichlorophenyl)-4-[2-[4-phenyl-1-azoniabicyclo[2.2.2]oct-1-yl]ethyl]-3-methyl-1-[3,5-bis(trifluoromethyl)benzyl]imidazolidin-2-one chloride A mixture of the compound obtained in the previous step and 0.35 g of 4-phenyl-1-azabicyclo[2.2.2]-octane in 1 ml of DMF is heated at 80° C. for 3 hours. After cooling to RT, the reaction mixture is poured into a mixture of 50 ml of water, 50 ml of DCM and 3 ml of concentrated HCl and stirred for 5 minutes. The precipitate formed is wrung, washed with water, with DCM and then with ether and dried to give 0.3 g of the expected product. M.p.=290 C.

Sources & evidence

ORD record
ord-319701ae572043b6b46fa18b8280283b
Source dataset
uspto-grants-2000_01
Patent number
US06011154

Reaction notes

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