Acetic Acid → HCID 17881135, compound

HRID 849381Notes

Reaction equation

HRID 849381 reaction equation
C(C[C:4]1[CH:5]=[C:6]([C:14]([O:16]C)=[O:15])[C:7](=[CH:12][CH:13]=1)[C:8]([O:10]C)=[O:9])#N.Cl.[C:19]([OH:22])(=[O:21])[CH3:20]>>[C:19]([CH2:20][C:4]1[CH:5]=[C:6]([C:14]([OH:16])=[O:15])[C:7](=[CH:12][CH:13]=1)[C:8]([OH:10])=[O:9])([OH:22])=[O:21]

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 19591478HCID 19591478, compound

Product 1

HCID 17881135HCID 17881135, compound

Conditions

Temperature
120 °C

Procedure

0.78 g of dimethyl 4-cyanomethylphthalate was dissolved in a mixed liquid comprising 15 ml of concentrated hydrochloric acid and 4 ml of acetic acid, followed by stirring under heating at 120° C. for 2.5 hours. The reaction solution was left to cool to room temperature and then extracted by an addition of ethyl acetate and water. The organic layer was post-treated in accordance with a usual method to obtain 0.53 g of the above identified compound as white solid.

Workup

  1. waitThe reaction solution was left
  2. temperatureto cool to room temperature
  3. extractionextracted by an addition of ethyl acetate and water
  4. additionThe organic layer was post-treated in accordance with a usual method
  5. customto obtain 0.53 g of the

Sources & evidence

ORD record
ord-cf14ed695228477abb7cac30b0a55aef
Source dataset
uspto-grants-2000_01
Patent number
US06011174

Reaction notes

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