Methanol → HCID 178478877, compound

HRID 849408Notes

Reaction equation

HRID 849408 reaction equation
[ClH:1].Br[C:3]1[CH:4]=[CH:5][C:6]2[N:12]([CH2:13][C:14]3[N:15]=[CH:16][NH:17][CH:18]=3)[CH2:11][CH2:10][N:9]([C:19]([C:21]3[C:30]4[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=4)[CH:24]=[CH:23][CH:22]=3)=[O:20])[CH2:8][C:7]=2[CH:31]=1.[CH3:32][OH:33]>>[ClH:1].[ClH:1].[OH:33][CH2:32][C:4]1[CH:3]=[CH:31][C:7]2[CH2:8][N:9]([C:19]([C:21]3[C:30]4[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=4)[CH:24]=[CH:23][CH:22]=3)=[O:20])[CH2:10][CH2:11][N:12]([CH2:13][C:14]3[N:15]=[CH:16][NH:17][CH:18]=3)[C:6]=2[CH:5]=1

Participants

3

Reactant 2

HCID 887MethanolHCID 1784796677-Bromo-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-4-(1-naphthalenylcarbonyl)-1H-1,4-benzodiazepine, hydrochloride

Product 1

HCID 178478877HCID 178478877, compound

Procedure

Example 274 was prepared as an off white solid from Compound B as described for Compound F of Example 41, with chromatography using 5% MeOH/0.5% NH4OH/methylene chloride, and Compound D of Example 1, with purification by prep HPLC before formation of the HCl salt. MS (M+H) 413.

Workup

  1. customwith purification by prep HPLC before formation of the HCl salt

Sources & evidence

ORD record
ord-5b56f5ea2088444ca8e2d886391574cd
Source dataset
uspto-grants-2000_01
Patent number
US06011029

Reaction notes

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