反应详情

温度

100 °C

A mixture of 4-fluorobenzenesulfonamide (6.95 g) and piperazine (17.1 g) in 30 mL of water is heated at 100° C. overnight. The solid is then collected, washed with water and toluene, and dried under reduced pressure to give 9.2 g of 4-(piperazin-1-yl)benzenesulfonamide; mp 219-221° C.; ms m/z 241; IR (mineral oil) 1160, 822, 1332, 608, 1593, 1137 cm-1. 1H NMR (DMSOd6) δ 2.81, 3.17, 2.3, 7.01, 7.07, 7.61.

1. customThe solid is then collected
2. washwashed with water and toluene
3. customdried under reduced pressure