Water → HCID 7732993, compound

Participants

Reaction Steps

To a solution of 20.8 g of o-anisidine in 140 ml of pyridine was added dropwise a solution of 35.2 g of p-trifluoromethyl benzoyl chloride in 30 ml of tetrahydrofuran at 50° to 10° C. After stirring at room temperature for 1.7 hours, the reaction mixture was poured into 1.6 liters of water. The precipitate was collected by filtration, washed with water, and dried to give 48.9 g of 4- trifluoromethyl -2'-methoxybenzanilide.

Provenance & Evidence