Water → HCID 7732993, compound

HRID 849501Notes

Reaction equation

HRID 849501 reaction equation
[CH3:1][O:2][C:3]1[C:4]([NH2:9])=[CH:5][CH:6]=[CH:7][CH:8]=1.[F:10][C:11]([F:22])([F:21])[C:12]1[CH:20]=[CH:19][C:15]([C:16](Cl)=[O:17])=[CH:14][CH:13]=1.O>N1C=CC=CC=1.O1CCCC1>[F:10][C:11]([F:21])([F:22])[C:12]1[CH:20]=[CH:19][C:15]([C:16]([NH:9][C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[O:2][CH3:1])=[O:17])=[CH:14][CH:13]=1

Participants

6

Reactant 3

HCID 962WaterHCID 70002-MethoxyanilineHCID 676074-(Trifluoromethyl)benzoyl chloride

Product 1

HCID 7732993HCID 7732993, compoundYield 98.1%

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 20.8 g of o-anisidine in 140 ml of pyridine was added dropwise a solution of 35.2 g of p-trifluoromethyl benzoyl chloride in 30 ml of tetrahydrofuran at 50° to 10° C. After stirring at room temperature for 1.7 hours, the reaction mixture was poured into 1.6 liters of water. The precipitate was collected by filtration, washed with water, and dried to give 48.9 g of 4- trifluoromethyl -2'-methoxybenzanilide.

Workup

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-bb3d65413c424af2a784452167ed0fdf
Source dataset
uspto-grants-2000_01
Patent number
US06013659

Reaction notes

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