HCID 67167490, compound → HCID 67167825, compound

HRID 84966Notes

Reaction equation

HRID 84966 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]2[C@H:9]3[CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][C@@H:10]3[CH2:21][CH2:22][O:23][C:5]=2[CH:4]=1.COC1C2[C@H]3CN(C(OC(C)(C)C)=O)C[C@@H]3CCOC=2C=CC=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]2[C@H:9]3[CH2:13][NH:12][CH2:11][C@@H:10]3[CH2:21][CH2:22][O:23][C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 67167490HCID 67167490, compoundHCID 86653466HCID 86653466, compound

Product 1

HCID 67167825HCID 67167825, compound

Procedure

The title compound was prepared as the hydrochloride salt as described in Example 272F substituting the product from Example 280E for the product obtained from Example 272E. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.69-1.86 (m, 1H) 1.86-2.03 (m, 1H) 2.03-2.14 (m, 1H) 2.84-3.03 (m, 1H) 3.12-3.27 (m, 1H) 3.35-3.47 (m, 1H) 3.47-3.63 (m, 2H) 3.64-3.76 (m, 4H) 4.31-4.47 (m, 1H) 6.53-6.73 (m, 2H) 7.00 (d, J=8.33 Hz, 1H) 9.26 (s, 2H); MS (DCI+) m/z 220.1 [M+H]+.

Sources & evidence

ORD record
ord-8f68b3cd6f6d4a37ab363d8fbbd3ea31
Source dataset
uspto-grants-2014_09
Patent number
US08846951B2

Reaction notes

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