Hydrochloric Acid → 7-Aminoheptan-1-ol

HRID 849716Notes

Reaction equation

HRID 849716 reaction equation
C([O:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][NH:12]C(=O)C)(=O)C.Cl>CO>[NH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][OH:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19367511HCID 19367511, compound

Product 1

HCID 139560317-Aminoheptan-1-ol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-Acetoxy-7-acetamidoheptane (11.8 g, 54.3 mmol) was dissolved in 20 mL of methanol in a 200 mL round bottom flask. To this was added 50 mL of 40% aqueous hydrochloric acid and the mixture was heated at reflux for 60 hours. All volatiles were removed under reduced pressure. The desired 7-amino-1-heptanol was obtained as the crystalline hydrochloride salt, m.p. 74-81° C., MS: 131 (MH+).

Workup

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 60 hours
  3. customAll volatiles were removed under reduced pressure

Sources & evidence

ORD record
ord-9f98a039b9a541da89582cf7073871f7
Source dataset
uspto-grants-2000_01
Patent number
US06013792

Reaction notes

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