Sodium Hydroxide → N'-t-butyl-N-benzoyl-N'-(2-thiophenecarbonyl)hydrazine

HRID 849783Notes

Reaction equation

HRID 849783 reaction equation
[C:1]([NH:5][NH:6][C:7](=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].[S:17]1[CH:21]=[CH:20][CH:19]=[C:18]1[C:22](Cl)=[O:23]>C1(C)C=CC=CC=1>[C:1]([N:5]([C:22]([C:18]1[S:17][CH:21]=[CH:20][CH:19]=1)=[O:23])[NH:6][C:7](=[O:14])[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 789282-Thiophenecarbonyl chlorideHCID 299436N'-tert-butylbenzohydrazide

Product 1

HCID 15452002N'-t-butyl-N-benzoyl-N'-(2-thiophenecarbonyl)hydrazine

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

N'-t-butyl-N-benzoylhydrazine (1.0 g) was dissolved in 20 ml toluene. 50% aqueous sodium hydroxide (1.25 g) was added followed by 2-thiophene-carbonylchloride (0.76 g). The mixture was stirred at room temperature for 14 hours. The solid product, N'-t-butyl-N-benzoyl-N'-(2-thiophenecarbonyl)hydrazine, was removed by filtration and washed with water. m.p. >200° C.

Workup

  1. customThe solid product, N'-t-butyl-N-benzoyl-N'-(2-thiophenecarbonyl)hydrazine, was removed by filtration
  2. washwashed with water

Sources & evidence

ORD record
ord-6985cd67d7c24b26ae4586520d9f0d6f
Source dataset
uspto-grants-2000_01
Patent number
US06013836

Reaction notes

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