Hydrochloric Acid → HCID 69834690, compound

Participants

Reaction Steps

5-[(1R)-1-{(2R)-2-tert-Butoxycarbonylamino-3-(2-naphthyl)propionylamino}-2-phenylethyl]-[1,2,4]oxadiazole-3-carboxylic acid ethyl ester (0.41 g, 0.7 mmol) was suspended in a saturated mixture of hydrogen chloride in ethyl acetate (10 ml). After 18 h at 20° C., the reaction mixture was filtered to give 0.39 g of 5-[(1R)-1-{(2R)-2-amino-3-(2-naphthyl)propionylamino}-2-phenylethyl]-[1,2,4]oxadiazole-3-carboxylic acid ethyl ester hydrochloride.

Provenance & Evidence