Hydrochloric Acid → HCID 69834690, compound

HRID 849832Notes

Reaction equation

HRID 849832 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[N:10]=[C:9]([C@H:11]([NH:19][C:20](=[O:41])[C@H:21]([NH:33]C(OC(C)(C)C)=O)[CH2:22][C:23]2[CH:32]=[CH:31][C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[CH:24]=2)[CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[O:8][N:7]=1)=[O:5])[CH3:2].[ClH:42]>C(OCC)(=O)C>[ClH:42].[CH2:1]([O:3][C:4]([C:6]1[N:10]=[C:9]([C@H:11]([NH:19][C:20](=[O:41])[C@H:21]([NH2:33])[CH2:22][C:23]2[CH:32]=[CH:31][C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[CH:24]=2)[CH2:12][C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[O:8][N:7]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53863218HCID 53863218, compound

Product 1

HCID 69834690HCID 69834690, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

5-[(1R)-1-{(2R)-2-tert-Butoxycarbonylamino-3-(2-naphthyl)propionylamino}-2-phenylethyl]-[1,2,4]oxadiazole-3-carboxylic acid ethyl ester (0.41 g, 0.7 mmol) was suspended in a saturated mixture of hydrogen chloride in ethyl acetate (10 ml). After 18 h at 20° C., the reaction mixture was filtered to give 0.39 g of 5-[(1R)-1-{(2R)-2-amino-3-(2-naphthyl)propionylamino}-2-phenylethyl]-[1,2,4]oxadiazole-3-carboxylic acid ethyl ester hydrochloride.

Workup

  1. filtrationthe reaction mixture was filtered

Sources & evidence

ORD record
ord-4b8fe10748f443fc9efa58afc3cb9112
Source dataset
uspto-grants-2000_01
Patent number
US06013658

Reaction notes

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