Trifluoroacetic acid → HCID 54562593, compound
Reaction equation
C(O[C:6](=O)[N:7]([C@@H:9]([CH2:17][O:18][CH2:19][CH2:20][OH:21])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)C)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH3:6][NH:7][C@H:9]([CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[CH2:17][O:18][CH2:19][CH2:20][OH:21]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
N-((1R)-1-(2-Hydroxyethoxymethyl)-2-phenylethyl)-N-methylcarbamic acid tert-butylester (0.29 g, 0.90 mmol) was dissolved in dichloromethane (3 mL). Trifluoroacetic acid (1 mL) was added. The solution was stirred at 0° C. for 15 min. The solvents were removed in vacuo. The residue was dissolved in dichloromethane (10 mL) and extracted with 1N sodium hydroxide (10 mL). The organic phase was dried over magnesium sulfate. The solvent was removed in vacuo to give 0.11 g of crude 2-((2R)-2-methylamino-3-phenylpropoxy)ethanol, which was used for further syntheses.
Workup
- customThe solvents were removed in vacuo
- dissolutionThe residue was dissolved in dichloromethane (10 mL)
- extractionextracted with 1N sodium hydroxide (10 mL)
- dry with materialThe organic phase was dried over magnesium sulfate
- customThe solvent was removed in vacuo
Sources & evidence
- ORD record
- ord-664ff37c8d374baaba144a2252f68c1a
- Source dataset
- uspto-grants-2000_01
- Patent number
- US06013658
Reaction notes
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