Tetrahydrofuran → Tetrahydropyranyl ether

Temperature

-30 °C

2-(3-Butynyloxy)tetrahydro-2H-pyran (112.5 g, 0.729 mole) was added dropwise to a solution of methyllithium (500 mL of MeLi 1AM in ether, 0.7 mole) in 1 L of anhydrous THF at -30° C. under argon atmosphere in a 5 L round bottom flask. After this addition was completed, the cooling bath was removed and the solution was allowed to stand at room temperature for 4 hours. The solution was cooled again at -30° C. and a solution of ketone 3 (75 g, 0.2 mole) in 2.5 L of anhydrous TTh was added dropwise. After completing this addition, the cooling bath was removed and the mixture was allowed to stand at room temperature for 16 h. To this mixture, 100 mL of brine were added and the solution was diluted with ethyl acetate, washed with brine and dried with anhydrous MgSO4. The solvent was then evaporated and crystallization took place after a short period of time. Hexane was added to complete the precipitation. The solid was then filtered and washed with hexane. The compound 4 was used in the next step without further purification. Yield: 95.8 g (90%). 1H NMR δ (CDCl3, 300 MHz, TMS): 0.82 (s, 3H, 18CH3), 1.01 (s, 3H, 19CH3), 2.52 (t, 2H, J=6.8 Hz, CCCH2), 3.15-3.44 (m, 4H, SCH2), 3.50-3.56 (m, 2H, CH2OTHP), 3.75-3.90 (m, 2H, pyran OCH2), 4.66 (s, 1H, OCHO), 5.47 (s, 1H, C-4H.

1. additionAfter this addition
2. customthe cooling bath was removed
3. additionthis addition
4. customthe cooling bath was removed
5. waitto stand at room temperature for 16 h
6. additionTo this mixture, 100 mL of brine were added
7. additionthe solution was diluted with ethyl acetate
8. washwashed with brine
9. dry with materialdried with anhydrous MgSO4
10. customThe solvent was then evaporated
11. customcrystallization
12. additionHexane was added
13. customthe precipitation
14. filtrationThe solid was then filtered
15. washwashed with hexane
16. customThe compound 4 was used in the next step without further purification

ORD record

ord-1004b09f666e4537a997508f28bd5b0a

Source dataset

uspto-grants-2000_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06015806