HCID 53850252, compound → HCID 18396914, compound

HRID 850089Notes

Reaction equation

HRID 850089 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]([OH:30])([C:16]([C:18]1[CH:23]=[CH:22][C:21]([C:24]2[N:28]([CH3:29])[N:27]=[CH:26][CH:25]=2)=[CH:20][CH:19]=1)=[CH2:17])[CH2:10][N:11]1[CH:15]=[N:14][CH:13]=[N:12]1>C(O)C.[Pd]>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]([OH:30])([C@H:16]([C:18]1[CH:23]=[CH:22][C:21]([C:24]2[N:28]([CH3:29])[N:27]=[CH:26][CH:25]=2)=[CH:20][CH:19]=1)[CH3:17])[CH2:10][N:11]1[CH:15]=[N:14][CH:13]=[N:12]1

Participants

4

Reactant 1

HCID 53850252HCID 53850252, compound

Product 1

HCID 18396914HCID 18396914, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of (2R)-2-(2,4-difluorophenyl)-3-(4-[1-methylpyrazol-5-yl]phenyl)-1-(1,2,4-triazol-1-yl)-3-buten-2-ol (2.0 g, 5 mmol-see Preparation 53) in ethanol (50 ml) was hydrogenated at 50 psi (333 KPa) pressure over 5% palladium on charcoal (0.2 g) for 18 hours at 50° C. A further batch of catalyst (0.2 g) was added, and the hydrogenation was continued for a further 18 hours. The mixture was filtered through "Arbocel" (Trade Mark) and the filtrate evaporated under reduced pressure.

Workup

  1. filtrationThe mixture was filtered through "Arbocel" (Trade Mark)
  2. customthe filtrate evaporated under reduced pressure

Sources & evidence

ORD record
ord-d428a364d7094d24bfad62f3ebb23ba5
Source dataset
uspto-grants-2000_01
Patent number
US06015825

Reaction notes

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