HCID 53850252, compound → HCID 18396914, compound

Participants

Reaction Steps

A solution of (2R)-2-(2,4-difluorophenyl)-3-(4-[1-methylpyrazol-5-yl]phenyl)-1-(1,2,4-triazol-1-yl)-3-buten-2-ol (2.0 g, 5 mmol-see Preparation 53) in ethanol (50 ml) was hydrogenated at 50 psi (333 KPa) pressure over 5% palladium on charcoal (0.2 g) for 18 hours at 50° C. A further batch of catalyst (0.2 g) was added, and the hydrogenation was continued for a further 18 hours. The mixture was filtered through "Arbocel" (Trade Mark) and the filtrate evaporated under reduced pressure.

Provenance & Evidence