HCID 19365965, compound → HCID 19365923, compound

HRID 850100Notes

Reaction equation

HRID 850100 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1([C:12]([C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH:24]=[N:23][CH:22]=[N:21]3)=[CH:16][CH:15]=2)=[CH2:13])[CH2:11][O:10]1.[NH:25]1[CH:29]=[N:28][CH:27]=[N:26]1.[Na]>CN(C=O)C>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]([OH:10])([C:12]([C:14]1[CH:19]=[CH:18][C:17]([N:20]2[CH:24]=[N:23][CH:22]=[N:21]2)=[CH:16][CH:15]=1)=[CH2:13])[CH2:11][N:25]1[CH:29]=[N:28][CH:27]=[N:26]1

Participants

4

Reactant 2

HCID 19365965HCID 19365965, compoundHCID 454898221h-1,2,4-Triazole sodium salt

Product 1

HCID 19365923HCID 19365923, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

By the method of Preparation 20(v), 2-(2,4-difluorophenyl)-2-[1-{4-(1,2,4-triazol-1-yl)phenyl}ethenyl]oxirane (570 mg, 1.75 mmol) was treated with sodium 1,2,4-triazole in DMF (10 ml) at 70° C. for 8 hours, to give 2-(2,4-difluorophenyl)-1-(1,2,4-triazol-1-yl)-3-[4-(1,2,4-triazol-1-yl)phenyl]-3-buten-2-ol (620 mg, 89%), as a solid, which was characterised by 1H-N.M.R. spectroscopy.

Sources & evidence

ORD record
ord-a1d18947503540da87b23ece62109e9f
Source dataset
uspto-grants-2000_01
Patent number
US06015825

Reaction notes

Loading…