2-Chlorobenzyl chloride → 2-(2-Chlorophenyl)-4'-iodoacetophenone

HRID 850110Notes

Reaction equation

HRID 850110 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[Cl:9].CON(C)[C:13]([C:15]1[CH:20]=[CH:19][C:18]([I:21])=[CH:17][CH:16]=1)=[O:14]>>[Cl:9][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[CH2:2][C:13]([C:15]1[CH:20]=[CH:19][C:18]([I:21])=[CH:17][CH:16]=1)=[O:14]

Participants

3

Reactant 2

HCID 119062-Chlorobenzyl chlorideHCID 54617564-Iodo-N-methoxy-N-methyl-benzamide

Product 1

HCID 193659622-(2-Chlorophenyl)-4'-iodoacetophenone

Procedure

The title compound was prepared from α,2-dichlorotoluene and O,N-dimethyl-4-iodobenzenehydroxamic acid (see Preparation 30) by a similar method to that of Preparation 20(i) as a colourless solid, m.p. 105-106° C., which was characterised by 1H-N.M.R. spectroscopy.

Sources & evidence

ORD record
ord-42d71a100361488785799ceb606b0af6
Source dataset
uspto-grants-2000_01
Patent number
US06015825

Reaction notes

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