alpha-Bromo-o-fluorotoluene → 2-(2-Fluorophenyl)-4'-iodoacetophenone

HRID 850111Notes

Reaction equation

HRID 850111 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4]Br.CON(C)[C:13]([C:15]1[CH:20]=[CH:19][C:18]([I:21])=[CH:17][CH:16]=1)=[O:14]>>[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][C:13]([C:15]1[CH:20]=[CH:19][C:18]([I:21])=[CH:17][CH:16]=1)=[O:14]

Participants

3

Reactant 2

HCID 67968alpha-Bromo-o-fluorotolueneHCID 54617564-Iodo-N-methoxy-N-methyl-benzamide

Product 1

HCID 193659392-(2-Fluorophenyl)-4'-iodoacetophenone

Procedure

The product was prepared from 2-fluorobenzyl bromide and O,N-dimethyl-4-iodobenzenehydroxamic acid (see Preparation 30) by a similar method to Preparation 20(i) as a colourless solid, m.p. 112-114° C.

Sources & evidence

ORD record
ord-20e099695ebc4c4d92f9fbd0a7999eca
Source dataset
uspto-grants-2000_01
Patent number
US06015825

Reaction notes

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