Methanamine, N-methoxy-, hydrochloride (1:1) → HCID 19365978, compound

HRID 850116Notes

Reaction equation

HRID 850116 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([I:11])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].Cl.[CH3:13][NH:14][O:15][CH3:16]>>[CH3:13][N:14]([C:4]([C:3]1[CH:7]=[CH:8][C:9]([I:11])=[CH:10][C:2]=1[F:1])=[O:5])[O:15][CH3:16]

Participants

3

Reactant 2

HCID 81138Methanamine, N-methoxy-, hydrochloride (1:1)HCID 27745162-Fluoro-4-iodobenzoic acid

Product 1

HCID 19365978HCID 19365978, compound

Procedure

The product was prepared from 2-fluoro-4-iodo-benzoic acid (EP-A-0327190) and N,O-dimethylhydroxylamine hydrochloride by a similar method to Preparation 30, as a yellow oil, b.p. 120-122° C. (0.5 mmHg), which was characterised by NMR. 1H-NMR (300OMHz, CDCl3): δ=3.44(s,3H), 3.53(s,3H), 7.14(t,1H), 7.51(d,1H), 7.56(dd,1H) ppm.

Sources & evidence

ORD record
ord-e2e6f82b0e694299b46bd7198c80d18a
Source dataset
uspto-grants-2000_01
Patent number
US06015825

Reaction notes

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