反应详情

A solution of 2-ethyl-5-bromopyridine (1.86 g, 10 mmol), N-bromosuccinimide (1.78 g, 10 mmol) in 1,2-dichloroethane (20 ml) was brought to reflux before the addition of azoisobutyronitrile (AIBN) (20 mg). The solution was then refluxed for a further two hours. The cooled suspension was filtered and evaporated in vacuo. Purification by column chromatography (silica gel, eluting with 1:1 dichloromethane/hexane) gave the desired product as a pale yellow oil (2.12 g, 80%).

1. temperatureThe solution was then refluxed for a further two hours
2. filtrationThe cooled suspension was filtered
3. customevaporated in vacuo
4. customPurification
5. washby column chromatography (silica gel, eluting with 1:1 dichloromethane/hexane)