反应详情

To a suspension of 1-(tert-butyldiphenylsilyloxymethyl)-2,6-dimethyl-3-nitrobenzene (42 g) and ammonium chloride (4.2 g) in ethanol (378 ml)-water (42 ml) was added iron (7.0 g), and the mixture was refluxed for 6 hours, during which iron (7.0 g) was added thereto twice. Insoluble materials were filtered off, and the filtrate was concentrated. To the residue was added water and extracted with ethyl acetate. The organic layer was washed with water and brine, dried over magnesium sulfate and concentrated to give 3-amino-1-(tert-butyldiphenylsilyloxymethyl)-2,6-dimethylbenzene (42.8 g) as pale yellow oil.

1. additionwas added
2. filtrationInsoluble materials were filtered off
3. concentrationthe filtrate was concentrated
4. additionTo the residue was added water
5. extractionextracted with ethyl acetate
6. washThe organic layer was washed with water and brine
7. dry with materialdried over magnesium sulfate
8. concentrationconcentrated