反应详情

温度

25 °C

To a solution of 2-(4-fluorophenyl)-1-phenyl-1-ethanone (5 g, 30 mmol) in 30 ml pyridine under nitrogen was added methoxylamine hydrochloride (3.8 g, 45 mmol) at 25° C. The resulting mixture was stirred at 25° C. for 17 hours. The pyridine was removed in vacuo with heating. The residual solids were a mixture of the oxime geometrical isomers as a white syrup and it was used for the next step without further purification. Rf : 0.48, 0.70 (CH2Cl2).

1. customThe pyridine was removed in vacuo
2. temperaturewith heating
3. additiona mixture of the oxime geometrical isomers as a white syrup and it
4. customwas used for the next step without further purification