Pyrrolidine → (3,5-Di-tert-butyl-4-hydroxy-phenyl)-(N-pyrollidinyl)-acetic acid ethyl ester

HRID 850338Notes

Reaction equation

HRID 850338 reaction equation
[C:1]([C:5]1[C:10](=[O:11])[C:9]([C:12]([CH3:15])([CH3:14])[CH3:13])=[CH:8][C:7](=[CH:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[NH:22]1[CH2:26][CH2:25][CH2:24][CH2:23]1>>[CH2:20]([O:19][C:17](=[O:18])[CH:16]([C:7]1[CH:6]=[C:5]([C:1]([CH3:2])([CH3:3])[CH3:4])[C:10]([OH:11])=[C:9]([C:12]([CH3:13])([CH3:14])[CH3:15])[CH:8]=1)[N:22]1[CH2:26][CH2:25][CH2:24][CH2:23]1)[CH3:21]

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 22019852Ethyl (3,5-di-t-butyl-4-oxocyclohexa-2,5-dienylidene)acetate

Product 1

HCID 9950820(3,5-Di-tert-butyl-4-hydroxy-phenyl)-(N-pyrollidinyl)-acetic acid ethyl ester

Procedure

Synthesized as in Example 51 from Intermediate 17 (0.54 g, 1.86 mmol) and pyrollidine (284 mg, 4.0 mmol). This gave 0.415 mg (62%) of product.

Sources & evidence

ORD record
ord-f49c264f0297495dbcdad9fb8273416a
Source dataset
uspto-grants-2000_01
Patent number
US06017918

Reaction notes

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