Morpholine → (3,5-Di-tert-butyl-4-hydroxy-phenyl)-(N-morpholinyl)-acetic acid ethyl ester

HRID 850340Notes

Reaction equation

Br[CH:2]([C:8]1[CH:13]=[C:12]([C:14]([CH3:17])([CH3:16])[CH3:15])[C:11]([OH:18])=[C:10]([C:19]([CH3:22])([CH3:21])[CH3:20])[CH:9]=1)[C:3]([O:5][CH2:6][CH3:7])=[O:4].[NH:23]1[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1>>[CH2:6]([O:5][C:3](=[O:4])[CH:2]([C:8]1[CH:13]=[C:12]([C:14]([CH3:17])([CH3:16])[CH3:15])[C:11]([OH:18])=[C:10]([C:19]([CH3:22])([CH3:21])[CH3:20])[CH:9]=1)[N:23]1[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1)[CH3:7]

Participants

Reactant 2

HCID 8083Morpholine

HCID 12018252Ethyl 2-bromo-(3,5-di-t-butyl-4-hydroxyphenyl)-acetate

Product 1

HCID 9907750(3,5-Di-tert-butyl-4-hydroxy-phenyl)-(N-morpholinyl)-acetic acid ethyl ester

Procedure

The compound was synthesized as in Example 17 from Intermediate 11 (4.0 g, 10.8 mmol) and morpholine (2.1 g, 24 mmol). This gave 0.91 g (22%) of pure product.

Sources & evidence

ORD record: ord-40e334e316c7438fa2913d9309b1bc00
Source dataset: uspto-grants-2000_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06017918

Reaction notes

Loading…