Hydrochloric Acid → HCID 19363363, compound

HRID 850510Notes

Reaction equation

HRID 850510 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][N:10]2[C:19](=[O:20])[C:18]3[C:13](=[C:14]([O:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[C:15]([O:21][CH3:22])=[CH:16][CH:17]=3)[NH:12][C:11]2=[O:29])=[CH:4][CH:3]=1.[ClH:30]>C(O)C>[ClH:30].[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][N:10]2[C:19](=[O:20])[C:18]3[C:13](=[C:14]([O:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[C:15]([O:21][CH3:22])=[CH:16][CH:17]=3)[NH:12][C:11]2=[O:29])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19363364HCID 19363364, compound

Product 1

HCID 19363363HCID 19363363, compoundYield 92.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

3-[2-(4-Aminophenyl)ethyl]-7-methoxy-8-pentyloxy-1H-quinazoline-2,4-dione (28.0 g, 70.4 mmol) obtained in Example 7-40 and ethanol (500 ml) were mixed, and the mixture was refluxed under heating until the crystals were completely dissolved. Concentrated hydrochloric acid (5.93 ml, 70.4 mmol) was added dropwise to this solution, and ethanol (200 ml) was further added. The mixture was cooled to room temperature, and the precipitated crystals were collected by filtration to give 3-[2-(4-aminophenyl)ethyl]-7-methoxy-8-pentyloxy-1H-quinazoline-2,4-dione hydrochloride (28.24 g, 92%) as colorless crystals.

Workup

  1. temperaturethe mixture was refluxed
  2. temperatureunder heating until the crystals
  3. dissolutionwere completely dissolved
  4. additionwas further added
  5. filtrationthe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-b33cbd2a440a4c3c8a991465b6da8a71
Source dataset
uspto-grants-2000_01
Patent number
US06017919

Reaction notes

Loading…