HCID 9824961, compound → HCID 9933529, compound

HRID 850634Notes

Reaction equation

HRID 850634 reaction equation
[O:1]1[C:5]2=[N:6][C:7]([CH:10]([N:15]3[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][CH2:22][C:23]4[CH:32]=[CH:31][C:30]5[CH2:29][CH2:28][CH2:27][NH:26][C:25]=5[N:24]=4)[C:16]3=[O:33])[CH2:11][C:12]([OH:14])=[O:13])=[CH:8][CH:9]=[C:4]2[CH:3]=[CH:2]1>CO.[Pd]>[O:1]1[C:5]2=[N:6][C:7]([CH:10]([N:15]3[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][CH2:22][C:23]4[CH:32]=[CH:31][C:30]5[CH2:29][CH2:28][CH2:27][NH:26][C:25]=5[N:24]=4)[C:16]3=[O:33])[CH2:11][C:12]([OH:14])=[O:13])=[CH:8][CH:9]=[C:4]2[CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 9824961HCID 9824961, compound

Product 1

HCID 9933529HCID 9933529, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 23-4 (360 mg, 0.80 mmol) in MeOH (10 mL) was treated with 10% Pd/C (100 mg) and stirred under a hydrogen atmosphere for 18 h. The catalyst was removed by filtration through celite and the residue chromatographed (75% 20:1:1 EtOH/NH4OH/H2O-25% EtOAc) to afford 23-5 as a colorless glass.

Workup

  1. customThe catalyst was removed by filtration through celite
  2. customthe residue chromatographed (75% 20:1:1 EtOH/NH4OH/H2O-25% EtOAc)

Sources & evidence

ORD record
ord-335ef4e5345c4f609a54c185f7019278
Source dataset
uspto-grants-2000_01
Patent number
US06017926

Reaction notes

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