Water → HCID 19364922, compound

HRID 850790Notes

Reaction equation

HRID 850790 reaction equation
[Br:1][C:2]1[CH:14]=[CH:13][C:12]2[C:11]3[C:6]4=[C:7]([C:24](=[O:27])[CH:25]=[CH:26][N:5]4[C:4]=2[CH:3]=1)[CH:8]=[C:9]([O:15][CH2:16][C:17]([O:19]C(C)(C)C)=[O:18])[CH:10]=3.O>C(O)(=O)C.Br>[Br:1][C:2]1[CH:14]=[CH:13][C:12]2[C:11]3[C:6]4=[C:7]([C:24](=[O:27])[CH:25]=[CH:26][N:5]4[C:4]=2[CH:3]=1)[CH:8]=[C:9]([O:15][CH2:16][C:17]([OH:19])=[O:18])[CH:10]=3

Participants

5

Reactant 2

HCID 962WaterHCID 21252854HCID 21252854, compound

Product 1

HCID 19364922HCID 19364922, compoundYield 92.1%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 260Hydrogen BromideSolvent

Procedure

9-bromo-2-t-butoxycarbonylmethyloxy-4H-pyrido[3,2,1-jk]carbazole-4-one (120 mg) produced in Example 118 was dissolved in acetic acid (5 ml) and 48% HBr (5 ml), and the solution was stirred at room temperature for 12 hours. The reaction mixture was poured into water and the crystals precipitated were recovered by filtration, and washed with water, ethanol and ether in succession to obtain the title compound (96 mg, 92%).

Workup

  1. customthe crystals precipitated
  2. filtrationwere recovered by filtration
  3. washwashed with water, ethanol and ether in succession

Sources & evidence

ORD record
ord-78341b3313de439aa324374ebe3faf6f
Source dataset
uspto-grants-2000_01
Patent number
US06018046

Reaction notes

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