Water → HCID 19364898, compound

HRID 850792Notes

Reaction equation

HRID 850792 reaction equation
[CH2:1]([C:8]1[C:9](=[O:27])[C:10]2[CH:11]=[C:12]([O:25]C)[CH:13]=[C:14]3[C:22]=2[N:21]([CH:23]=1)[C:20]1[CH:19]=[C:18]([Br:24])[CH:17]=[CH:16][C:15]3=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O>C(O)(=O)C.Br>[CH2:1]([C:8]1[C:9](=[O:27])[C:10]2[CH:11]=[C:12]([OH:25])[CH:13]=[C:14]3[C:22]=2[N:21]([CH:23]=1)[C:20]1[CH:19]=[C:18]([Br:24])[CH:17]=[CH:16][C:15]3=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 962WaterHCID 21252837HCID 21252837, compound

Product 1

HCID 19364898HCID 19364898, compoundYield 58.2%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 260Hydrogen BromideSolvent

Procedure

5-benzyl-9-bromo-2-methoxy-4H-pyrido[3,2,1-jk]carbazole-4-one (137 mg) produced in Example 121 was dissolved in acetic acid (7 ml) and 48% HBr (7 ml), and the solution was stirred at room temperature for 30 hours. The reaction mixture was poured into water and the crystals precipitated were recovered by filtration, and washed with water, ethanol and ether in succession to obtain the title compound (77 mg, 58%).

Workup

  1. customthe crystals precipitated
  2. filtrationwere recovered by filtration
  3. washwashed with water, ethanol and ether in succession

Sources & evidence

ORD record
ord-8d282aef0ee8408a81b3555b6a30adfd
Source dataset
uspto-grants-2000_01
Patent number
US06018046

Reaction notes

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