Acetyl chloride → HCID 178475066, compound

HRID 850859Notes

Reaction equation

HRID 850859 reaction equation
N([CH2:3][C:4]([NH:6][C@H:7]([C:16]1[O:17][C:18]([CH3:21])=[CH:19][N:20]=1)[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=1)=[O:5])C.[CH2:22]([NH:29][C:30](=[O:54])[C@H:31]([CH2:47][CH2:48][CH2:49][NH:50][C:51](=[NH:53])[NH2:52])[NH:32][C:33](=[O:46])[C@H:34]([CH3:45])[NH:35][CH:36]1[CH2:41][CH2:40][CH:39]([C:42]([OH:44])=[O:43])[CH2:38][CH2:37]1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.C(Cl)(=O)C>>[C:4]([NH:6][C@H:7]([C:16]1[O:17][C:18]([CH3:21])=[CH:19][N:20]=1)[CH2:8][C:9]1[CH:10]=[CH:11][C:12]([F:15])=[CH:13][CH:14]=1)(=[O:5])[CH3:3].[CH2:22]([NH:29][C:30](=[O:54])[C@H:31]([CH2:47][CH2:48][CH2:49][NH:50][C:51](=[NH:52])[NH2:53])[NH:32][C:33](=[O:46])[C@H:34]([CH3:45])[NH:35][CH:36]1[CH2:37][CH2:38][CH:39]([C:42]([OH:44])=[O:43])[CH2:40][CH2:41]1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 178484728HCID 178484728, compound

Product 1

HCID 178475066HCID 178475066, compound

Procedure

Compound 9 was prepared by the method described for the preparation of compound 7 from AC2 (1.2 mmol) and acetyl chloride (1.2 mmol), and isolated as a white powder (0.10 g): mp 111-116° C.; FAB-MS m/e 705 (MH+). Anal. calcd. for C37H49N8O5F·1.0 TFA·1.0 anisole·1.0 H2O (901.78): C, 57.54; H, 6.35; N, 12.43; KF, 2.0. Found: C, 57.71; H, 6.27; N, 12.49; KF, 2.32.

Sources & evidence

ORD record
ord-f77891ee50164301a9e5a25f8ba0674f
Source dataset
uspto-grants-2000_01
Patent number
US06017890

Reaction notes

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