HCID 22942128, compound → HCID 86753708, compound

HRID 850863Notes

Reaction equation

HRID 850863 reaction equation
[CH2:1]([O:8][C:9](=[O:78])[C@H:10]([CH2:74][CH:75]([CH3:77])[CH3:76])[NH:11][C:12](=[O:73])[C@H:13]([C:69]([CH3:72])([CH3:71])[CH3:70])[NH:14][C:15](=[O:68])[C@H:16]([CH2:60][C:61]1[CH:66]=[CH:65][CH:64]=[CH:63][C:62]=1[CH3:67])[NH:17][C:18](=[O:59])[C@H:19]([CH2:50][CH2:51][C:52](=[O:58])[O:53][C:54]([CH3:57])([CH3:56])[CH3:55])[NH:20][C:21](=[O:49])[C@H:22]([CH2:41][C:42](=[O:48])[O:43][C:44]([CH3:47])([CH3:46])[CH3:45])[NH:23]C(OCC1C2C=CC=CC=2C2C1=CC=CC=2)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>N1CCCCC1.ClCCl>[CH2:1]([O:8][C:9](=[O:78])[C@H:10]([CH2:74][CH:75]([CH3:76])[CH3:77])[NH:11][C:12](=[O:73])[C@H:13]([C:69]([CH3:72])([CH3:71])[CH3:70])[NH:14][C:15](=[O:68])[C@H:16]([CH2:60][C:61]1[CH:66]=[CH:65][CH:64]=[CH:63][C:62]=1[CH3:67])[NH:17][C:18](=[O:59])[C@H:19]([CH2:50][CH2:51][C:52](=[O:58])[O:53][C:54]([CH3:55])([CH3:56])[CH3:57])[NH:20][C:21](=[O:49])[C@H:22]([CH2:41][C:42](=[O:48])[O:43][C:44]([CH3:45])([CH3:46])[CH3:47])[NH2:23])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 22942128HCID 22942128, compound

Product 1

HCID 86753708HCID 86753708, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8082PiperidineSolvent

Procedure

A solution of 10.088 g (9.4 mmol) of N-[N-[N-[N-[N-[(9-fluorenyl)methoxycarbonyl] O-tert-butyl-L-α-aspartyl]-O-tert-butyl-L-α-glutamyl]-2-methyl-L-phenylalanyl]-3-methyl-L-valyl]-L-leucine benzyl ester in 30 ml of piperidine and 120 ml of dichloromethane was stirred for 30 minutes at room temperature. The solvent was removed by evaporation and the residue was chromatographed on silica gel using firstly 20% ethyl acetate in hexane and then 10% methanol in dichloromethane for the elution. Evaporation gave N-[N-[N-[N-[O-tert-butyl-L-α-aspartyl]-O-tert-butyl-L-α-glutamyl-2-methyl-L-phenylalanyl]-3-methyl-L-valyl-L-leucine benzyl ester in the form of an oil which was used in the next step without further purification.

Workup

  1. customThe solvent was removed by evaporation
  2. customthe residue was chromatographed on silica gel using firstly 20% ethyl acetate in hexane
  3. wash10% methanol in dichloromethane for the elution
  4. customEvaporation

Sources & evidence

ORD record
ord-3893053371dd4e5f89036301fbfbe66d
Source dataset
uspto-grants-2000_01
Patent number
US06018020

Reaction notes

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