Hydrochloric Acid → HCID 178485078, compound
Reaction equation
[CH3:1][NH:2][C:3]([NH:7][CH2:8][CH2:9][S:10][CH2:11][C:12]1[N:13]=[C:14]([CH2:17][N:18]([CH3:20])[CH3:19])[S:15][CH:16]=1)=[N:4][C:5]#[N:6].[ClH:21].C([OH:24])C>>[ClH:21].[ClH:21].[CH3:1][NH:2][C:3]([NH:7][CH2:8][CH2:9][S:10][CH2:11][C:12]1[N:13]=[C:14]([CH2:17][N:18]([CH3:19])[CH3:20])[S:15][CH:16]=1)=[N:4][C:5]([NH2:6])=[O:24]Participants
Procedure
Aout 0.6 g. of N-methyl-N'-2-(2-dimethylaminomethyl-4-thiazolylmethylthio)ethyl-N"-cyanoguanidine were dissolved in 8 ml. of 1.5 N aqueous hydrochloric acid. The resulting solution was allowed to remain at ambient temperature for about four days. Volatile constituents were then removed by evaporation in vacuo. The resulting residue, comprising N-methyl-N'-2-(2-dimethylaminomethyl-4-thiazolylmethylthio)ethyl-N"-aminocarbonylguanidine dihydrochloride formed in the above reaction, was dissolved in ethanol and the ethanol removed by evaporation. The residue obtained thereby was recrystallized from isopropanol. The crystalline product was collected and digested with ethyl acetate. The ethyl acetate was removed by evaporation and the product obtained was crystallized from isopropanol to yield N-methyl-N'-2-(2-dimethylaminomethyl-4-thiazolylmethylthio)ethyl-N"-aminocarbonylguanidine dihydrochloride melting at 156.5°-159.5° C.
Workup
- customVolatile constituents were then removed by evaporation in vacuo
- customformed in the above reaction
- customthe ethanol removed by evaporation
- customThe residue obtained
- customthereby was recrystallized from isopropanol
- customThe crystalline product was collected
- customThe ethyl acetate was removed by evaporation
- customthe product obtained
- customwas crystallized from isopropanol
Sources & evidence
- ORD record
- ord-bd45fc5262ff482ea0a5923e9f781507
- Source dataset
- uspto-grants-1983_05
- Patent number
- US04382090
Reaction notes
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