HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 13145527, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | 1,3,4-Thiadiazol-2-amine | HCID 19909 | — |
| Reactant | Benzyloxycarbonyl-L-phenylalanine | HCID 70878 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 13145527 | HCID 13145527 | 71.2% |
Reaction Steps
Using the same procedure as in Example 1(i), 10 g of N-benzyloxycarbonyl-L-phenylalanine, 3.3 g of triethylamine, 3.7 g of ethyl chlorocarbonate and 3.5 g of 2-amino-1,3,4-thiadiazole were reacted in chloroform to obtain 9.1 g (yield: 71%) of 2-(N-benzyloxycarbonyl-L-phenylalanylamino)-1,3,4-thiadiazole as white crystals of mp: 78°-83° C. and [α]D20 : +28.0° (C=1.2, MeOH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04382142 |
| Source dataset | uspto-grants-1983_05 |
| ORD ID | ord-0526b9daf5404f4aafe410fb1f34ba9d |
| Source note | uspto-grants-1983_05 |