反应详情

A mixture of 4.4 g. of 2-carbamyl-4-hexadecylaminothiophene, 50 ml. of methyl cellosolve, and 50 ml. of 6 N hydrochloric acid is refluxed for 40 hours and then allowed to cool. The solid is filtered and recrystallized from methanol. The solid is then dissolved in hot sodium bicarbonate solution, filtered, and the filtrate is acidified with concentrated hydrochloric acid. The resulting precipitate is collected and recrystallized from isopropanol to yield the product.

1. additionA mixture of 4.4 g
2. temperatureto cool
3. filtrationThe solid is filtered
4. customrecrystallized from methanol
5. dissolutionThe solid is then dissolved in hot sodium bicarbonate solution
6. filtrationfiltered
7. customThe resulting precipitate is collected
8. customrecrystallized from isopropanol
9. customto yield the product