Sodium Hydroxide → 5-Hexadecylamino-2-thiophenecarboxylic acid

Participants

Reaction Steps

A mixture of 0.1 g. of ethyl 5-hexadecylamino-2-thiophenecarboxylate, 10 ml. of absolute ethanol and 10 ml. of 0.5 N sodium hydroxide is refluxed for 3 hours. The reaction mixture is cooled and then concentrated. The pH of the solution is adjusted to 5.3 and the resulting solid filtered and dried to yield the product.

Provenance & Evidence